Peyronie’s Disease

Have a Question?

We are here to help make things easier for you, so please contact us with any questions you might happen to have. We will be happy to answwer them and put you at ease.

What is Peyronie’s disease

Peyronie’s Disease, also known as acquired penile curvature is a condition characterized by the formation of scars in the tunica albuginea of the penis. 

These plaques, which can cause pain during erections, penile curvature, shortening of the shaft and worsening of the quality of erections, can be often easily palpated as a lump along the penile shaft. 

Plaques tend to be tender for a few months during the initial acute phase of the disease, when an inflammatory process is associated with the deposition of the scar tissue.

Peyronie’s Disease plaques cause loss of elasticity of the tunica of the penis and this reduces the capacity of the penis to stretch during erections. This is the reason why patients commonly complain of penile shortening and deformity such as curvature and narrowing of the penile shaft. In the flaccid state the plaques can sill be easily palpated along the shaft at the preliminary examination of the penis, but the deformity cannot be appreciated.

There is a very strong link between Peyronie’s Disease and the other known cardiovascular risk factors, such as diabetes, high blood pressure, high cholesterol and triglycerides levels, obesity and tobacco consumption. 

In particular, it is estimated that around two thirds of patients with Peyronie’s Disease have at least one of the known cardiovascular risk factor.

Progressive worsening of the quality of the erections is rather common in patients affected by Peyronie’s Disease and this could have various explanations.  Although the plaque itself can potentially cause erectile dysfunction, as it alters the veno-occlusive mechanism, which is responsible of retaining the blood in the corpora cavernosa during erections, certainly cardiovascular risk factors are likely to play a significant role by affecting the arteries feeding the penis, with consequent reduction the blood inflow into the corpora cavernosa of the penis.
Peyronie’s Disease can be cause of severe distress both for the patient and his partner due to penile pain, shortening, deformity and worsening of the quality of the erection and therefore is important to offer a targeted and effective treatment to this condition.

The cause of Peyronie’s disease still remains unknown, although it is suspected that this condition may occur in the genetically predisposed patient following trauma to the erect penis. In fact, around 30% of patients report that they experienced a trauma during intercourse before the onset of the disease. A genetic predisposition certainly plays an important role causing an imbalance in the growth factors that finely regulate the healing process following tissue damage. Ultimately this imbalance leads to excessive tissue proliferation at the level of the tunica albuginea. 

The natural history of Peyronie’s Disease can be subdivided into an acute and a chronic phase. The initial acute phase is characterized by the progressive formation of the plaque at the level of the tunica albuginea, which is tender at palpation and when stretched in the erect state as there is an active localized inflammatory process. As the inflammatory process is still active, plaque size and the characteristics of the deformity tend to change over time during the acute phase. The acute phase finishes and the chronic one begins when the inflammatory process eventually subsides, usually within 9 months from the onset of Peyronie’s Disease. In the chronic phase usually there is no pain during erections or when palpating the plaque and the degree of the deformity stabilizes. 


Am I suffering from Peyronie’s Disease?

If you think that you are suffering from Peyronie’s Disease, it would be advisable for you to book a consultation with Mr Garaffa.

Mr Garaffa is one of the world leading experts in the management of Peyronie’s Disease and he has also been involved in the production of the most recent international consensus guidelines on this condition.

Due to pain, deformity, shortening and worsening of the quality of erections, Peyronie’s Disease can be cause of severe distress both for the patient and the partner and therefore you should seek a permanent solution to your problem.
Every case of Peyronie’s Disease is different as the type of deformity, the quality of erection and the degree of penile shortening vary significantly among patients. Therefore, following a thorough consultation, Mr Garaffa will discuss with you which treatment options are likely to give you the best result and you will then be able to decide which procedure to have.

Why Choose Giulio

Giulio is a veteran surgeon with 15 years of experience in the field of Andrology and Reconstruction. He is also one of the largest penile prosthesis implanters in Europe, as well as the surgeon who performs the largest number of procedures for the correction of complex cases of Peyronie's disease. He has been invited to lecture and perform surgery in 21 different countries, in 6 different continents.


Penile prosthesis implants last year


Complex Andrological procedures every year


Phalloplasties over his career